CBD Research Studies

At Stono Creek Apothecary, we believe wellness decisions should be informed ones. The CBD research studies below are pulled directly from peer-reviewed medical journals and organized by topic — so you can explore the science behind cannabidiol, hemp, and the endocannabinoid system for yourself.

These CBD research studies cover everything from pain and inflammation to anxiety, sleep, skin health, and addiction. An asterisk (*) denotes studies where only an abstract is available and full access may require a purchase.

For a plain-language breakdown of what this research means in practice, read our guide on how CBD works in the body, or browse our products.

Disclaimer: The research studies linked below are provided for informational purposes only and have been compiled from publicly available sources. Stono Creek Apothecary has not independently reviewed, verified, or endorsed the findings of these studies. This page does not constitute medical advice. These statements have not been evaluated by the Food and Drug Administration. Our products are not intended to diagnose, treat, cure, or prevent any disease. Please consult a qualified healthcare provider before making any health decisions.

 

 

Addiction

 

• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
• Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence
• * Cannabis as a substitute for alcohol and other drugs
• Interactions between delta9-tetrahydrocannabinol and heroin: self-administration in rhesus monkeys
• Medical Cannabis Laws and Opioid Analgesic Overdose Mortality in the United States, 1999-2010

 

Alzheimer’s/Dementia

 

• A Molecular Link Between the Active Component of Marijuana and Alzheimer’s Disease Pathology
• Amyloid-beta inhibits E-S Potentiation through suppression of cannabinoid receptor 1-dependent synaptic disinhibition
• Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids
• Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease
• Alzheimer’s disease; taking the edge off with cannabinoids?
• Cannabinoids and Dementia: A Review of Clinical and Preclinical Data
• * Cannabinoids and Parkinson’s disease
• * Cannabinoids for the treatment of agitation and aggression in Alzheimer’s disease
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
• * Cannabinoids for the treatment of dementia
• Cannabidiol and other cannabinoids reduce microglial activation in vitro and in vivo: relevance to Alzheimer’s disease
• CB2 Cannabinoid Receptor As Potential Target against Alzheimer’s Disease
• * Chronic cannabidiol treatment improves social and object recognition in double transgenic APPswe/PS1∆E9 mice
• * Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
• Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
• * Safety and efficacy of medical cannabis oil for behavioral and psychological symptoms of dementia: An-open label, add-on, pilot study
• Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer’s disease
• Synthetic cannabinoids in dementia with agitation: Case studies and literature review
• The influence of cannabinoids on generic traits of neurodegeneration
• * The potential therapeutic effects of THC on Alzheimer’s disease
• * The role of the endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer’s disease

 

Amyotrophic Lateral Sclerosis (ALS)

 

• * Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid
• * Cannabinol delays symptom onset in SOD1 transgenic mice without affecting survival
• * Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials
• * Increasing cannabinoid levels by pharmacological and genetic manipulation delay disease progression in SOD1 mice
• * Survey of cannabis use in patients with amyotrophic lateral sclerosis

 

 

Antibacterial

 

• Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
• Antimicrobial Activity of Cannabis sativa L.
• Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
• In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains
  Marijuana, Tetrahydrocannabinol, and Pulmonary Antibacterial Defenses

 

Antioxidant

 

• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• * Mechanism for inhibitory effect of cannabidiol on microsomal testosterone oxidation in male rat liver
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Prospects for cannabinoid therapies in basal ganglia disorders

 

Antiprion

 

• Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity

 

Anxiety

 

• * Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects
• * Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa
• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
• Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients
• Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety-related and substance abuse disorders
• Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
• Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors
• Effects of Cannabidiol (CBD) on Regional Cerebral Blood
• * Effects of ipsapirone and cannabidiol on human experimental anxiety
• Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
• Medical cannabis and mental health: A guided systematic review
• * Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report
• * Overexpression of CB2 cannabinoid receptors decreased vulnerability to anxiety and impaired anxiolytic action of alprazolam in mice
• * Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence
• * Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

 

Appetite

 

• Cannabidiol Attenuates the Appetitive Effects of Δ₉-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• Endocannabinoids, feeding and suckling – from our perspective
• Endogenous cannabinoid system as a modulator of food intake
• Hypothalamic POMC neurons promote cannabinoid-induced feeding

 

Arnold-Chiari Malformation and Syringomyelia

 

• A survey of cannabis (marijuana) use and self-reported benefit in men with chronic prostatitis/chronic pelvic pain syndrome
• * Cannabinoids and multiple sclerosis
• * Cannabis use for chronic non-cancer pain: results of a prospective survey
• * Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been…
• * Delta-9-tetrahydrocannabinol-cannabidiol (Sativex): a review of its use in patients with moderate to severe spasticity due to multiple sclerosis
• * Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

 

Arthritis

 

• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
• Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
• Cannabinoid-mediated antinociception is enhanced in rat osteoarthritic knees
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Cannabinoid WIN‑55,212‑2 mesylate inhibits ADAMTS‑4 activity in human osteoarthritic articular chondrocytes by inhibiting expression of syndecan‑1
• Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1b induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression in human chondrocytes
• Characterisation of the Cannabinoid Receptor System in Synovial Tissue and Fluid in Patients With Osteoarthritis and Rheumatoid Arthritis
• * Involvement of the endocannabinoid system in osteoarthritis pain
• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
• Suppression of tumour necrosis factor production from mononuclear cells by a novel synthetic compound, CLX-090717
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis

 

Attention Deficit Hyperactivity Disorder (ADHD)

 

• Association of the Cannabinoid Receptor Gene (CNR1) With ADHD and Post-Traumatic Stress Disorder
• Cannabis improves symptoms of ADHD
• * Cannabinoid-induced conditioned place preference in the spontaneously hypertensive rat–an animal model of attention deficit hyperactivity disorder
• Drug Reinforcement in a Rat Model of Attention Deficit-Hyperactivity Disorder – The Spontaneously Hypertensive Rat (SHR)

 

Autism

 

• * Alternations in the endocannabinoid system in the rat valproic acid model of autism
• Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling
• * Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
• Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders
• Deficient Social and Play Behavior in Juvenile and Adult Rats after Neonatal Cortical Lesion: Effects of Chronic Pubertal Cannabinoid Treatment
• Endocannabinoid System as Novel Therapeutic Target for Autism Treatment
• Method for predicting autism spectrum disorders by cannabinoid and cannabinoid receptor expression
• Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
• Uncoupling of the endocannabinoid signaling complex in a mouse model of fragile X syndrome
• Use of dronabinol (delta-9-THC) in autism: A prospective single-case-study with an early infantile autistic child
• Variation in the human cannabinoid receptor CNR1 gene modulates gaze duration for happy faces

 

Autoimmune

 

• Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD Mice
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

 

Autonomic Dysfunction

 

• Blurred Boundaries: The Therapeutics and Politics of Medical Marijuana
• Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
• Cannabinoid CB2 receptor activation attenuates motor and autonomic function deficits in a mouse model of spinal cord injury
• * Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis
• Cannabinoid pharmacology: the first 66 years
• Cannabinoid Receptor 2 Signaling in Neurodegenerative Disorders: From Pathogenesis to a Promising Therapeutic Target
• * Cannabinoids and experimental models of multiple sclerosis
• Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta
• Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
• Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart
• Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• * The endocannabinoid system and its therapeutic exploitation
• The endocannabinoid system as an emerging target of pharmacotherapy
• Vascular targets for cannabinoids: animal and human studies

 

Batten Disease

 

• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
• siRNA knockdown of GPR18 receptors in BV-2 microglia attenuates N-arachidonoyl glycineinduced cell migration

 

Blood Pressure

 

• A systematic review and meta-analysis of the haemodynamic effects of cannabidiol
• A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
• Blood pressure regulation by endocannabinoids and their receptors
• Is the cardiovascular system a therapeutic target for cannabidiol?
• * Safety and side effects of cannabidiol, a cannabis sativa constituent

 

Bone Health

 

• Activation of cannabinoid receptor 2 enhances osteogenic differentiation of bone marrow derived from mesenchymal stem cells
• Cannabidiol, a Major Non-Psychotropic Cannabis Constituent Enhances Fracture Healing and Stimulates Lysyl Hydroxylase Activity in Osteoblasts
• Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
• Cannabinoids and the skeleton: from marijuana to reversal of bone loss
• Cannabinoid receptors and the regulation of bone mass
• Mechanical and material properties of cortical and trabecular bone from cannabinoid receptor-1-null (Cnr1(-/-)) mice
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
• Role of cannabinoids in the regulation of bone remodeling
• * The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling

 

Breast Cancer

 

• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• *Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
• *Cannabinoids: A new hope for breast cancer therapy?
• Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
• Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
• Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
• Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
• Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation

 

Cachexia (Wasting Syndrome)

 

• Cannabidiol Attenuates the Appetitive Effects of Δ₉-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• * Cannabinoids in the treatment of the cachexia-anorexia syndrome in palliative care patients
• Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial
• Cannabis use in HIV for pain and other medical symptoms
• Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS
• Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study
• * Effect of dronabinol therapy on physical activity in anorexia nervosa: a randomised, controlled trial
• Endocannabinoids, feeding and sucking – from our perspective
• Endogenous cannabinoid system as a modulator of food intake
• Hypothalamic POMC neurons promote cannabinoid-induced feeding
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection

 

Cancer

 

• A cannabinoid quinone inhibits angiogenesis by targeting vascular endothelial cells
• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Anandamide Induces Apoptosis in Human Cells via Vanilloid Receptors
• * Antiangiogenic activity of the endocannabinoid anandamide: Correlation to its tumor-suppressor efficacy
• * Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration
• Anticancer mechanisms of cannabinoids
• * Antiemetic Effect of Delta-9-Tetrahydrocannabinol in Patients Receiving Cancer Chemotherapy
• Anti-proliferative effects of anandamide in human hepatocellular carcinoma cells
• Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy
• Antitumor Activity of Plant Cannabinoids with Emphasis on the Effect of Cannabidiol on Human Breast Carcinoma
• Antitumorigenic Effects of Cannabinoids beyond Apoptosis
• * Association between cannabis use and the risk of bladder cancer: results from the California Men’s Health Study
• Cannabidiol (CBD) Priming Enhances Cisplatin Killing Of Cancer Cells
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabidiol as potential anticancer drug
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy
• Cannabidiol inhibits angiogenesis by multiple mechanisms
• * Cannabidiol Inhibits Cancer Cell Invasion Via Upregulation Of Tissue Inhibitor Of Matrix Metalloproteinases-1
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
• Cannabidiol Inhibits Growth and Induces Programmed Cell Death in Kaposi Sarcoma–Associated Herpesvirus Infected Endothelium
• * Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• * Cannabidiolic acid-mediated selective down-regulation of c-fos in highly aggressive breast cancer MDA-MB-231 cells: possible involvement of its down-regulation in the abrogation of aggressiveness
• Cannabinoid-associated cell death mechanisms in tumor models (Review)
• Cannabinoid receptor 1 is a potential drug target for treatment of translocation-positive rhabdomyosarcoma
• Cannabinoid Receptor Agonist as an Alternative Drug in 5-Fluorouracil-resistant Gastric Cancer Cells
• Cannabinoid receptor ligands as potential anticancer agents – high hopes for new therapies
• Cannabinoid Receptor-Mediated Apoptosis Induced by R()-Methanandamide and Win55,212-2 Is Associated with Ceramide Accumulation and p38 Activation in Mantle Cell Lymphoma
• * Cannabinoid receptors as novel targets for the treatment of melanoma
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• * Cannabinoids: A new hope for breast cancer therapy?
• * Cannabinoids and cancer
• * Cannabinoids and cancer: potential for colorectal cancer therapy
• Cannabinoids and cancer: pros and cons of an antitumour strategy
• * Cannabinoids and ceramide: two lipids acting hand-by-hand
• * Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators
• Cannabinoids as therapeutic agents in cancer: current status and future implications
• Cannabinoids, Endocannabinoids and Cancer
• Cannabinoids for Cancer Treatment: Progress and Promise
• Cannabinoids induce apoptosis of pancreatic tumor cells via endoplasmic reticulum stress-related genes
• Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas
• * Cannabinoids in the treatment of the cachexia-anorexia syndrome in palliative care patients
• Cannabinoids: potential antitumoral agents?
• Cannabinoids Protect Astrocytes from Ceramide-induced Apoptosis through the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
• Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition
• * Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells
• Cannabis and Cannabinoids (PDQ®) – National Cancer Institute | Patient
• Cannabis and Cannabinoids (PDQ®) – National Cancer Institute | Healthcare Professional
• Cannabis in cancer care
• Cannabis Extract Treatment for Terminal Acute Lymphoblastic Leukemia with a Philadelphia Chromosome Mutation
• CBD inhibits angiogenesis by multiple mechanisms
• * Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
• Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
• Comparison of Orally Administered Cannabis Extract and Delta-9-Tetrahydrocannabinol in Treating Patients With Cancer-Related Anorexia-Cachexia Syndrome: A Multicenter, Phase III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial From the Cannabis-In-Cachexia-Study-Group
• COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
• Delta-9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• * Delta-9-tetrahydrocannabinol interferes with the establishment and the expression of conditioned rejection reactions produced by cyclophosphamide: a rat model of nausea
• Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized-double-blind, placebo-controlled pilot trial
• * Differential role of cannabinoids in the pathogenesis of skin cancer
• Down-regulation of cyclooxygenase-2 (COX-2) by cannabidiolic acid in human breast cancer cells
• Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study
• * Endocannabinoids and Cancer
• * Endocannabinoids and fatty acid amides in cancer inflammation and related disorders
• Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (Review)
• Endocannabinoids as Guardians of Metastasis
• Endocannabinoids in endocrine and related tumours
• Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedules
• Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
• Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
• Expression and Functional Relevance of Cannabinoid Receptor 1 in Hodgkin Lymphoma
• Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation
• High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
• Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target
• Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor
• In vitro and in vivo efficacy of non-psychoactive cannabidiol in neuroblastoma
• Increasing Antiproliferative Properties of Endocannabinoids in N1E-115 Neuroblastoma Cells through Inhibition of Their Metabolism
• Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1
• Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
• * Inhibition of tumor angiogenesis by cannabinoids
• Integrating cannabis into clinical cancer care
• Involvement of PPARc in the antitumoral action of cannabinoids on hepatocellular carcinoma
• Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
• Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study
• Medical marijuana for cancer
• Medical Marijuana Use in Oncology
• Microarray and Pathway Analysis Reveal Distinct Mechanisms Underlying Cannabinoid-Mediated
• Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent
• Modulation of LPS-Induced Activation of BV-2 Microglial Cells
• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC: CBD extract and THC extract in patients with intractable cancer-related pain
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
• NTP Toxicology and Carcinogenesis Studies of 1-Trans-Delta(9)-Tetrahydrocannabinol (CAS No. 1972-08-3) in F344 Rats and B6C3F1 Mice (Gavage Studies)
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation
• Potentiation of Cannabinoid-Induced Cytotoxicity in Mantle Cell Lymphoma through Modulation of Ceramide Metabolism
• Potentiation of the antitumor activity of adriamycin against osteosarcoma by cannabinoid WIN-55,212-2
• * Preparation and characterisation of biodegradable microparticles filled with THC and their antitumor efficacy on cancer cell lines
• Proapoptotic effect of endocannabinoids in prostate cancer cells
• Receptor-dependent and Receptor-independent Endocannabinoid Signaling: A Therapeutic Target for Regulation of Cancer Growth
• Regulation of nausea and vomiting by cannabinoids
• * Structure-dependent inhibitory effects of synthetic cannabinoids against 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and skin tumour promotion in mice
• Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
• Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling
• Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease
• Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
• The Antitumor Activity of Plant-Derived Non-Psychoactive Cannabinoids
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• * The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway
• The combination of cannabidiol and Δ9-tetrahydrocannabinol enhances the anticancer effects of radiation in an orthotopic murine glioma model
• The effects of cannabidiol and its synergism with bortezomib in multiple myeloma cell lines. A role for transient receptor potential vanilloid type-2
• The endocannabinoid system and cancer: therapeutic implication
• The endogenous cannabinoid anandamide inhibits human breast cancer cell proliferation
• The Expression Level of CB1 and CB2 Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas
• The Medical Necessity for Medicinal Cannabis: Prospective, Observational Study Evaluating the Treatment in Cancer Patients on Supportive or Palliative Care
• The potential relevance of the endocannabinoid, 2- arachidonoylglycerol, in diffuse large B-cell lymphoma
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications
• The role of cannabinoids in the treatment of children with cancer
• The stress-regulated protein p8 mediates cannabinoid-induced apoptosis of tumor cells
• The use of cannabinoids as anticancer agents
• * Therapeutic use of Cannabis sativa on chemotherapy-induced nausea and vomiting among cancer patients: systematic review and meta-analysis
• * Towards the use of cannabinoids as antitumour agents
• United States patent application publication for phytocannabinoids in the treatment of cancer

 

Cannabidiol (CBD)

 

• Action of Cannabidiol on the Anxiety and Other Effects Produced by D9-THC in Normal Subjects
• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
• Cannabidiol in Humans—The Quest for Therapeutic Targets
• Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
• Identification of Psychoactive Degradants of Cannabidiol in Simulated Gastric and Physiological Fluid
• Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent

 

CBDV

 

• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

 

Cardiovascular

 

• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• * An ultra-low dose of tetrahydrocannabinol provides cardioprotection
• A systematic review and meta-analysis of the haemodynamic effects of cannabidiol
• A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study
• Blood pressure regulation by endocannabinoids and their receptors
• * Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabidiol reduces brain damage and improves functional recovery after acute hypoxia-ischemia in newborn pigs
• Cannabinoids in experimental stroke: a systematic review and meta-analysis
• Cannabis use: signal of increasing risk of serious cardiovascular disorders
• Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta
• Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
• *Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
• Endocannabinoids Acting at Cannabinoid-1 Receptors Regulate Cardiovascular Function in Hypertension
• Is the cardiovascular system a therapeutic target for cannabidiol?
• *Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Role of Endocannabinoids and Cannabinoid-1 Receptors in Cerebrocortical Blood Flow Regulation
• *The effect of cannabidiol on ischemia/reperfusion-induced ventricular arrhythmias: the role of the adenosine A1 receptors
• * The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic–ischemic brain damage in mice is mediated by CB2 and adenosine receptors
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Vascular targets for cannabinoids: animal and human studies

 

CB1 Receptor

 

• Allosteric Modulation of the Cannabinoid CB1 Receptor
• Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor
• Cannabinoid CB1 receptor binding and acetylcholinesterase inhibitory activity of Sceletium tortuosum L.
• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Enhanced acetylcholine release in the hippocampus of cannabinoid
• Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
• Immunohistochemical analysis of cannabinoid receptor 1 expression in steatotic rat livers
• Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
• Presynaptically Located CB1 Cannabinoid Receptors Regulate GABA Release from Axon Terminals of Specific Hippocampal Interneurons

 

CB2 Receptor

 

• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor

 

Cellular Function

 

• Cannabidiol is a Potent Inhibitor of the Catalytic Activity of Cytochrome P450 2C19
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
• Characterization of P-glycoprotein Inhibition by Major Cannabinoids from Marijuana

 

Cerebral Palsy

 

• * Cannabinoid mouth spray brought help to a severely spastic young man
• Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature
• Survey Results of Pain Treatments in Adults with Cerebral Palsy

 

Chronic Traumatic Encephelopathy (CTE)

 

• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• * An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• * Cannabinoids and brain injury: therapeutic implications
• CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• * Effect of Marijuana Use on Outcomes in Traumatic Brain Injury
• Endocannabinoids: A Promising Impact for Traumatic Brain Injury
• Endocannabinoids and traumatic brain injury
• Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors
• Mechanisms of cannabidiol neuroprotection in hyopoxic-ischemic newborn pigs: role of 5HT(1A) and CB2 receptors
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
• * The endocannabinoid 2-AG protects the blood-brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The neuroprotective effect of cannabidiol in an in vitro model of newborn hypoxic-ischemic brain damage in mice is mediated by CB(2) and adenosine receptors

 

Chronic Obstructive Pulmonary Disease (COPD)

 

• β-Caryophyllene Inhibits Dextran Sulfate Sodium-Induced Colitis in Mice through CB2 Receptor Activation and PPARγ Pathway
• * Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects
• * Beneficial effects of cannabinoids (CB) in a murine model of allergen-induced airway inflammation: role of CB1/CB2 receptors
• Brochodiltor Effect of Δ1-Tetrahydrocannabinol
• Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury
• Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety
• Cannabinoids, endocannabinoids, and related analogs in inflammation
• Cannabinoids inhibit cholinergic contraction in human airways through prejunctional CB1 receptors
• Cannabinoids Tetrahydrocannabinol and Cannabidiol Differentially Inhibit the Lipopolysaccharide-activated NF-κB and Interferon-β/STAT Proinflammatory Pathways in BV-2 Microglial Cells
• Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
• * Cannabidiol improves lung function and inflammation in mice submitted to LPS-induced acute lung injury
• * CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma
• Effects of cannabis on pulmonary structure, function and symptoms
• Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors
• Impact of cannabis, cannabinoids, and endocannabinoids in the lungs
• Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB₂) receptor activation
• Marijuana and chronic obstructive lung disease: a population-based study
• Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
• * Preclinical assessment of novel therapeutics on the cough reflex: cannabinoid agonists as potential antitussives

 

Cognition

 

• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Keep off the grass Cannabis? Cognition and addiction

 

Colon Cancer

 

• Cannabinoid receptor activation induces apoptosis through tumor necrosis factor alpha-mediated ceramide de novo synthesis in colon cancer cells
• Growth inhibition and induction of apoptosis in colorectal tumor cells by cyclooxygenase inhibitors
• Induction of Apoptosis by Cannabinoids in Prostate and Colon Cancer Cells Is Phosphatase Dependent
• The cannabinoid δ9-tetrahydrocannabinol inhibits RAS-MAPK and PI3K-AKT survival signalling and induces BAD-mediated apoptosis in colorectal cancer cells
• The endogenous cannabinoid, anandamide, induces cell death in colorectal carcinoma cells: a possible role for cyclooxygenase 2
• The endogenous cannabinoid, anandamide, induces COX-2-dependent cell death in apoptosis-resistant colon cancer cells

 

Crohn’s Disease

 

• Cannabis Alleviates Symptoms Of Crohn’s Disease
• * Cannabis for Inflammatory Bowel Disease
• Cannabis Finds Its Way into Treatment of Crohn’s Disease
• Cannabis induces a clinical response in patients with Crohn’s disease: a prospective placebo-controlled study
• Endocannabinoid system acts as a regulator of immune homeostasis in the gut
• * Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study
• Marijuana use patterns among patients with inflammatory bowel disease
• * Protective effect of cannabidiol against cadmium hepatoxicity in rats
• The effects of Δ⁹-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• * Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Treatment of Crohn’s Disease with Cannabis: An Observational Study

 

D9-Tetrahydrocannabinol (THC)

 

• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Activity of cannabis in relation to its delta’-trans-tetrahydro-cannabinol content
• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• BRONCHODILATOR EFFECT OF Δ1-TETRAHYDROCANNABINOL
• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol Attenuates the Appetitive Effects of Δ9-Tetrahydrocannabinol in Humans Smoking Their Chosen Cannabis
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• D9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• D9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity
• Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
• Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
• Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
• Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

 

D9-Tetrahydrocannabinolic acid (THCA)

 

• Can You Pass the Acid Test? Critical Review and Novel Therapeutic Perspectives of D9-Tetrahydrocannabinolic Acid A
• Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

 

Depression

 

• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects

 

Diabetes

 

• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabinoids Regulate Bcl-2 and Cyclin D2 Expression in Pancreatic β Cells
• Novel Study Reports Marijuana Users Have Better Blood Sugar Control
• Presence of functional cannabinoid receptors in human endocrine pancreas
• The Endocannabinoid System and Plant-Derived Cannabinoids in Diabetes and Diabetic Complications
• The endocannabinoid system in obesity and type 2 diabetes

 

Drug Interactions

 

• A Phase I, open-label, randomized, crossover study in three parallel groups to evaluate the effect of Rifampicin, Ketoconazole, and Omeprazole on the pharmacokinetics of THC/CBD oromucosal spray in healthy volunteers
• Cannabis and its effect on anesthesia

 

Eczema

 

• *Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study)
• *Anti-inflammatory activity of topical THC in DNFB-mediated mouse allergic contact dermatitis independent of CB1 and CB2 receptors
• *Cannabidiol—transdermal delivery and anti-inflammatory effect in a murine model
• *Cannabinoid agonists attenuate capsaicin‐induced responses in human skin
• Cannabinoid system in the skin – a possible target for future therapies in dermatology
• Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB 1 receptors
• *Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study
• Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities
• The role of cannabinoids in dermatology

 

Edema

 

• Sex differences in anti-allodynic, anti-hyperalgesic and anti-edema effects of Δ9-tetrahydrocannabinol in the rat

 

Emesis

 

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Regulation of nausea and vomiting by cannabinoids
• The effects of cannabidiol and tetrahydrocannabinol on motion-induced emesis in Suncus murinus
• The Nonpsychoactive Cannabinoid Cannabidiol Inhibits 5-Hydroxytryptamine3A Receptor-Mediated Currents in Xenopus laevis Oocytes

 

Endocannabinoid System (ECS)

 

• Biphasic Effects of Cannabinoids on Acetylcholine Release in the Hippocampus: Site and Mechanism of Action
• Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
• Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor
• Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors
• Cannabinoid pharmacology: the first 66 years
• Cannabinoid Receptors CB1 and CB2 Form Functional Heteromers in Brain
• Cannabis, a complex plant: different compounds and different effects on individuals
• Care and Feeding of the Endocannabinoid System: A Systematic Review of Potential Clinical Interventions that Upregulate the Endocannabinoid System
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
• Dose-related differences in the regional pattern of cannabinoid receptor adaptation and in vivo tolerance development to delta9-tetrahydrocannabinol
• Endocannabinoid Signaling Regulates Sleep Stability
• Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol
• Enhanced discriminative stimulus effects of 9-THC in the presence of cannabidiol and 8-OH-DPAT in rhesus monkeys
• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
• Evidence that the plant cannabinoid cannabigerol is a highly potent a2-adrenoceptor agonist and moderately potent 5HT1A receptor antagonist
• Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)
• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system
• Modulating the endocannabinoid system in human health and disease: successes and failures
• Pharmacokinetics and metabolism of the plant cannabinoids, delta9-tetrahydrocannabinol, cannabidiol and cannabinol
• Targeting the endocannabinoid system with cannabinoid receptor agonists- pharmacological strategies and therapeutic possibilities
• The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Δ9-tetrahydrocannabinol, cannabidiol and Δ9-tetrahydrocannabivarin
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease
• The Endocannabinoid System as an Emerging Target of Pharmacotherapy
• The Endocannabinoid System, Cannabinoids, and Pain
• The endocannabinoid system in normal and pathological brain ageing
• The endogenous cannabinoid system and its role in nociceptive behavior
• The orphan receptor GPR55 is a novel cannabinoid receptor

 

Endocrine System

 

• Estrogen Receptor Beta and 2-arachidonoylglycerol Mediate the Suppressive Effects of Estradiol on Frequency of Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons of Metestrous Mice: An Acute Slice Electrophysiological Study
• Presence of functional cannabinoid receptors in human endocrine pancreas
• The effects of delta9-tetrahydrocannabinol and cannabidiol on the metabolism of gonadal steroids in the rat

 

Epilepsy

 

• Activation of the Cannabinoid Type-1 Receptor Mediates the Anticonvulsant Properties of Cannabinoids in the Hippocampal Neuronal Culture Models of Acquired Epilepsy and Status Epilepticus
• Analysis of endocannabinoid signaling elements and related proteins in lymphocytes of patients with Dravet syndrome
• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
• Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders
• Cannabidiol Rescues Acute Hepatic Toxicity and Seizure Induced by Cocaine
• Cannabidivarin (CBDV) suppresses pentylenetetrazole (PTZ)-induced increases in epilepsy-related gene expression
• Cannabidivarin is anticonvulsant in mouse and rat
• Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism
• Cannabinoids for pediatric epilepsy? Up in smoke or real science?
• Cannabis, Cannabinoids and Tinnitus
• Cannabis In The Management And Treatment Of Seizures And Epilepsy: A Scientific Review
• CBD-enriched medical cannabis for intractable pediatric epilepsy; The current Israeli experience
• Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients
• On the application of cannabis in paediatrics and epileptology
• Parent use of cannabis for intractable pediatric epilepsy: Everyday empiricism and the boundaries of scientific medicine
• Redistribution of CB1 Cannabinoid Receptors in the Acute and Chronic Phases of Pilocarpine-Induced Epilepsy
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
• The case for assessing cannabidiol in epilepsy
• The case for medical marijuana in epilepsy
• The Endogenous Cannabinoid System Regulates Seizure Frequency and Duration in a Model of Temporal Lobe Epilepsy
• Understanding Cannabinoids and Epilepsy

 

Epstein-Barr Virus (EBV)

 

• Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro

 

Fibromyalgia

 

• Association of Herbal Cannabis Use With Negative Psychosocial Parameters in Patients With Fibromyalgia
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes
• Marijuana Rated Most Effective for Treating Fibromyalgia

 

Fibrosis

 

• Cannabinoids and Cystic Fibrosis: A Novel Approach to Etiology and Therapy

 

Gastrointestinal Disease

 

• Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
• Cannabinoids and the gastrointestinal tract
• Cannabis Alleviates Symptoms Of Crohn’s Disease
• Cannabis Finds Its Way into Treatment of Crohn’s Disease
• Cannabis use amongst patients with inflammatory bowel disease
• Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism
• Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease
• Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Treatment of Crohn’s Disease with Cannabis: An Observational Study

 

General

 

• Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
• Cannabinoids in health and disease
• Cannabis sativa: The Plant of the Thousand and One Molecules
• Future of Cannabis and Cannabinoids in Therapeutics
• Medical Marijuana: Clearing Away the Smoke
• Pharmacological actions and therapeutic uses of cannabis and cannabinoids
• Phytocannabinoids beyond the Cannabis plant – do they exist?
• Plant cannabinoids: a neglected pharmacological treasure trove
• Review on clinical studies with cannabis and cannabinoids 2010-2014
• Safety and Toxicology of Cannabinoids
• Therapeutic aspects of cannabis and cannabinoids
• Therapeutic Benefits of Cannabis: A Patient Survey
• The Therapeutic Potential of Cannabis and Cannabinoids

 

Glaucoma

 

• Cannabinoids and glaucoma
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

 

Glioblastoma

 

• A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Delta 9-tetrahydrocannabinol inhibits cell cycle progression by downregulation of E2F1 in human glioblastoma multiforme cells
• Id-1 Is a Key Transcriptional Regulator of Glioblastoma Aggressiveness and a Novel Therapeutic Target

 

Glioma

 

• A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma
• Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
• Cannabidiol, a Non-Psychoactive Cannabinoid Compound, Inhibits Proliferation and Invasion in U87-MG and T98G Glioma Cells through a Multitarget Effect
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
• Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
• Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression
• Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
• Δ9-Tetrahydrocannabinol induces apoptosis in C6 glioma cells
• Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor

 

Hashimoto’s Thyroiditis/Graves’ Disease

 

• *Cannabinoids decrease the th17 inflammatory autoimmune phenotype
• *Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism
• *The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice

 

Herpes Virus

 

• Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro
• The effect of delta-9-tetrahydrocannabinol on herpes simplex virus replication
• Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside
• Cannabis May Help Combat Cancer-causing Herpes Viruses
• Effects of Cannabinoids on T-cell Function and Resistance to Infection
• Suppressive effect of delta-9-tetrahydrocannabinol on herpes simplex virus infectivity in vitro
• Delta-9 tetrahydrocannabinol (THC) inhibits lytic replication of gamma oncogenic herpesviruses in vitro

 

HIV

 

• Cannabinoid inhibits HIV-1 Tat-stimulated adhesion of human monocyte-like cells to extracellular matrix proteins

 

Human Papillomavirus (HPV)

 

• Short-term efficacy of CBD-enriched hemp oil in girls with dysautonomic syndrome after human papillomavirus vaccination

 

Huntington’s Disease

 

• Structure, expression and regulation of the cannabinoid receptor gene (CB1) in Huntington’s disease transgenic mice
• Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity

 

Immune Function

 

• Cannabidiol reduces host immune response and prevents cognitive impairments in Wistar rats submitted to pneumococcal meningitis
• Cannabinoid receptor activation leads to massive mobilization of myeloid-derived suppressor cells with potent immunosuppressive properties
• Cannabinoids and the immune system
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• D9-Tetrahydrocannabinol-Induced Apoptosis in the Thymus and Spleen as a Mechanism of Immunosuppression in Vitro and in Vivo
• Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
• Histone Modifications Are Associated with Delta (9)-tetrahydrocannabinol-Mediated Alterations in Antigen-Specific T Cell Responses

 

Infant Development

 

• Endocannabinoids, feeding and suckling – from our perspective
• Endocannabinoids potently protect the newborn brain against AMPA-kainate receptor-mediated excitotoxic damage
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

 

Inflammation

 

• Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
• Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis
• Cannabidiol reduces lipopolysaccharide-induced vascular changes and inflammation in the mouse brain: an intravital microscopy study
• Cannabinoid CB2 receptors in human brain inflammation
• Cannabinoid CB2 receptors in the gastrointestinal tract: a regulatory system in states of inflammation
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Cannabinoids in models of chronic inflammatory conditions
• Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
• Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabinomimetic Control of Mast Cell Mediator Release: New Perspective in Chronic Inflammation
• Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
• Evaluation of the Cyclooxygenase Inhibiting Effects of Six Major Cannabinoids Isolated from Cannabis sativa
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Oxyradical Stress, Endocannabinoids, and Atherosclerosis
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
• The effects of Δ9-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

 

Inflammatory Bowel Disease

 

• A clinical study showed that cannabis produces significant clinical benefits in patients with Crohn’s disease, including a reduction in pain sensation, nausea relief and reduce the feeling of unpleasantness.
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Clinical Endocannabinoid Deficiency Reconsidered: Current Research Supports the Theory in Migraine, Fibromyalgia, Irritable Bowel, and Other Treatment-Resistant Syndromes

 

Ischemia

 

• Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
• HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

 

Kidney

 

• Cannabidiol Attenuates Cisplatin-Induced Nephrotoxicity by Decreasing Oxidative/Nitrosative Stress, Inflammation, and Cell Death

 

Krabbe Disease

 

• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• CB2 cannabinoid receptors as an emerging target for demyelinating diseases: from neuroimmune interactions to cell replacement strategies
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
• The endocannabinoid system as a target for the treatment of neurodegenerative disease
• The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
• Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis

 

Leukemia

 

• *γ-Irradiation Enhances Apoptosis Induced by Cannabidiol, a Non-psychotropic Cannabinoid, in Cultured HL-60 Myeloblastic Leukemia Cells
• Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
• Cannabidiol for the Prevention of Graft-versus-Host-Disease after Allogeneic Hematopoietic Cell Transplantation: Results of a Phase II Study
• Cannabinoids induce incomplete maturation of cultured human leukemia cells
• *Cannabinoids: potential anticancer agents
• *Cannabis-induced cytotoxicity in leukemia cell lines: the role of the cannabinoid receptors and the MAPK pathway
• Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation
• D9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells Is Regulated by Translocation of Bad to Mitochondria
• Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns
• Enhancing the Activity of Cannabidiol and Other Cannabinoids In Vitro Through Modifications to Drug Combinations and Treatment Schedule
• *Enhancing the in vitro cytotoxic activity of Delta9-tetrahydrocannabinol in leukemic cells through a combinatorial approach

 

Liver

 

• Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
• Endocannabinoids in Liver Disease
• Exogenous hepatitis B virus envelope proteins induce endoplasmic reticulum stress: involvement of cannabinoid axis in liver cancer cells
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

 

Lung Cancer

 

• Cannabinoid Receptors, CB1 and CB2, as Novel Targets for Inhibition of Non-Small Cell Lung Cancer Growth and Metastasis
• Cannabinoids for Cancer Treatment: Progress and Promise
• COX-2 and PPAR-g Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
• Δ9-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration in vitro as well as its growth and metastasis in vivo
• Marijuana Use and the Risk of Lung and Upper Aerodigestive Tract Cancers: Results of a Population-Based Case-Control Study

 

Lupus

 

• Cannabinoids as Novel Anti-Inflammatory Drugs
• The analgesic potential of cannabinoids
• Endogenous Interleukin-1 Receptor Antagonist Mediates Anti-Inflammatory and Neuroprotective Actions of Cannabinoids in Neurons and Glia

 

Lyme Disease

 

• Antibacterial activity of Δ9-­tetrahydrocannabinol and cannabidiol
• Antibacterial Cannabinoids from Cannabis sativa: A Structure-Activity Study
• Antimicrobial Activity of Cannabis sativa L.
• Extraction of cannabinoids from cannabis sativa L plant and its potential antimicrobial activity
• In vitro antibacterial activity of Cannabis sativa leaf extracts to some selective pathogenicbacterial strains

 

Macular Degeneration

 

• Mediation of Cannabidiol anti-inflammation in the Retina by Equilibrative Nucleoside Transporter and A2A Adenosine Receptor*
• Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity

 

Memory

 

• Impact of cannabidiol on the acute memory and psychotomimetic effects of smoked cannabis: naturalistic study
• Non-acute (residual) neurocognitive effects of cannabis Use: A meta-analytic study
• On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
• The cannabinoid receptor agonist WIN 55-212-2 facilitates the extinction of contextual fear memory and spatial memory in rats
• Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons

 

Mental Illness

 

• Adolescent Exposure to Chronic Delta-9-Tetrahydrocannabinol Blocks Opiate Dependence in Maternally Deprived Rats
• β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice
• Brain CB2 Receptors: Implications for Neuropsychiatric Disorders
• Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
• Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-Induced Heroin Seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
• Cannabidiol as a potential treatment for psychosis
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol, neuroprotection and neuropsychiatric disorders
• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
• Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
• Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential
• Cannabis as a substitute for alcohol and other drugs
• CB1 cannabinoid receptor stimulation during adolescence impairs the maturation of GABA function in the adult rat prefrontal cortex
• Distinct Neurobehavioural Effects of Cannabidiol in Transmembrane Domain Neuregulin 1 Mutant Mice
• Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
• Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood
• Long term marijuana users seeking medical cannabis in California (2001–2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants
• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report – ResearchGate
• Opposite Effects of D-9-Tetrahydrocannabinol and Cannabidiol on Human Brain Function and Psychopathology
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• The Development of Cannabidiol as a Psychiatric Therapeutic: A Review of Its Antipsychotic Efficacy and Possible Underlying Pharmacodynamic Mechanisms
• The endocannabinoid system and emotional Processing: A pharmacological fMRI study with Δ9-tetrahydrocannabinol
• Therapeutical use of the cannabinoids in psychiatry

 

Migraine

 

• Activation of CB2 receptors as a potential therapeutic target for migraine: evaluation in an animal model
• Clinical Endocannabinoid Deficiency (CECD): Can this Concept Explain Therapeutic Benefits of Cannabis in Migraine, Fibromyalgia, Irritable Bowel Syndrome and other Treatment-Resistant Conditions
• Clinical endocannabinoid deficiency (CECD) revisited: Can this concept explain the therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions
• Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It’s Been
• Effects of anandamide in migraine: data from an animal model
• Endocannabinoids in the Brainstem Modulate Dural Trigeminovascular Nociceptive Traffic via CB1 and “Triptan” Receptors: Implications in Migraine
• The endocannabinoid system and migraine

 

Mitochondria

 

• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
• Cannabidiol Targets Mitochondria to Regulate Intracellular Ca2 Levels
• Mitochondria: a possible nexus for the regulation of energy homeostasis by the endocannabinoid system

 

MTHFR Gene Mutation

 

• Anti-inflammatory effects of the cannabidiol derivative dimethylheptyl-cannabidiol – studies in BV-2 microglia and encephalitogenic T cells
• Cannabidiol affects the expression of genes involved in zinc homeostasis in BV-2 microglial cells
• Cannabidiol Post-Treatment Alleviates Rat Epileptic-Related Behaviors and Activates Hippocampal Cell Autophagy Pathway Along with Antioxidant Defense in Chronic Phase of Pilocarpine-Induced Seizure
• Cannabidiol Protects against Doxorubicin-Induced Cardiomyopathy by Modulating Mitochondrial Function and Biogenesis
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors

 

Multiple Sclerosis

 

• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Cannabinoid Modulation of Neuroinflammatory Disorders
• Cannabinoids and multiple sclerosis
• Cannabinoids control spasticity and tremor in a multiple sclerosis model
• Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial
• Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up
• Cannabinoids in the management of spasticity associated with multiple sclerosis
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
• Effects of cannabis on cognitive function in patients with multiple sclerosis
• Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
• Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
• Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
• Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
• THC:CBD Observational Study Data: Evolution of Resistant MS Spasticity and Associated Symptoms
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The effect of cannabis on tremor in patients with multiple sclerosis
• The Endocannabinoid System Is Dysregulated in Multiple Sclerosis and in Experimental Autoimmune Encephalomyelitis
• Therapeutic Action of Cannabinoids in a Murine Model of Multiple Sclerosis
• Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

 

National Institute on Drug Abuse (NIDA)

 

• NIDA Research on the Therapeutic Benefits of Cannabis and Cannabinoids

 

Nausea

 

• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Cannabinoid Regulation of Acute and Anticipatory Nausea
• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
• Regulation of nausea and vomiting by cannabinoids

 

Nervous System

 

• Cannabinoid–Dopamine Interaction in the Pathophysiology and Treatment of CNS Disorders
• Direct suppression of autoreactive lymphocytes in the central nervous system via the CB2 receptor
• Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
• “The Therapeutic Potential of Cannabinoids for Movement
  Disorders | Nervous System”

 

Neuro-protective and Neuro-generative

 

• Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures
• Cannabidiol and (−)Δ9-tetrahydrocannabinol are neuroprotective antioxidants
• Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid
• Cannabidiol inhibits pathogenic T cells, decreases spinal microglial activation and ameliorates multiple sclerosis-like disease in C57BL/6 mice
• Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement
• Cannabinoid receptor CB1 mediates baseline and activity-induced survival of new neurons in adult hippocampal neurogenesis
• Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
• Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
• Cannabinoids: Well-Suited Candidates for the Treatment of Perinatal Brain Injury
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• CB1 Cannabinoid Receptors and On-Demand Defense Against Excitotoxicity
• Comparison of Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
• Endocannabinoid Signaling In Neurotoxicity And Neuroprotection
• Endocannabinoids and traumatic brain injury
• Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection
• Long-­term behavioral and biochemical effects of an ultra-­low dose of Δ9-­tetrahydrocannabinol (THC): neuroprotection and ERK signaling
• Molecular mechanisms of cannabinoid protection from neuronal excitotoxicity
• Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity
• Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol in Experimental Diabetes
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• Neuroprotective Effect of(−)Δ9-Tetrahydrocannabinol and Cannabidiol in N-Methyl-d-Aspartate-Induced Retinal Neurotoxicity
• Nonpsychoactive Cannabidiol Prevents Prion Accumulation and Protects Neurons against Prion Toxicity
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist
• Prospects for cannabinoid therapies in basal ganglia disorders
• Protective effects of Δ9-tetrahydrocannabinol against N-methyl-D-aspartate-induced AF5 cell death
• Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity
• The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia
• The cannabinoids: An overview. Therapeutic implications in vomiting and nausea after cancer chemotherapy, in appetite promotion, in multiple sclerosis and in neuroprotection
• The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K Akt mTORC1 BDNF pathway
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The endocannabinoid system as a target for the treatment of neurodegenerative disease
• The endocannabinoid system in normal and pathological brain ageing
• Δ9-Tetrahydrocannabinol Prevents Methamphetamine-Induced Neurotoxicity

 

Non-Hodgkin’s Lymphoma

 

• Expression of cannabinoid receptors type 1 and type 2 in non-Hodgkin lymphoma: Growth inhibition by receptor activation

 

Nutrition

 

• An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
• The Composition of Hemp Seed Oil and Its Potential as an Important Source of Nutrition

 

Obesity

 

• An Increase in the Omega-6-Omega-3 Fatty Acid Ratio Increases the Risk for Obesity
• Cannabinoid receptor 2 as anti-obesity target: inflammation, fat storage and browning modulation
• Pathophysiological role of host microbiota in the development of obesity
• The cannabinoid Δ9-tetrahydrocannabivarin (THCV) ameliorates insulin sensitivity in two mouse models of obesity

 

Obsessive Compulsive Disorder (OCD)

 

• Facilitation of CB1 receptor-mediated neurotransmission decreases marble burying

 

Optic Function

 

• Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys

 

Organ Transplants

 

• Marijuana Use in Potential Liver Transplant Candidates

 

Pain

 

• Amygdala activity contributes to the dissociative effect of cannabis on pain perception
• Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers- an updated review
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• Cannabinoid CB2 Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint
• Cannabinoid receptors and pain
• Cannabinoids delivery systems based on supramolecular inclusion complexes and polymeric nanocapsules for treatment of neuropathic pain
• Cannabinoids for treatment of chronic non-cancer pain; a systematic review of randomized trials
• Cannabinoids in the management of difficult to treat pain
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabis for the Management of Pain: Assessment of Safety Study (COMPASS)
• Clinical Implications for Cannabinoid Use in the Rheumatic Diseases
• Impact of Marijuana on Children and Adolescents
• Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Prescribing cannabis for harm reduction
• Role of Cannabinoids in Pain Management
• Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes
• Smoked cannabis for chronic neuropathic pain: a randomized controlled trial
• Stable dose cannabinoid medicine GW
• Survey Results of Pain Treatments in Adults with Cerebral Palsy
• Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
• Targeting CB2 receptors and the endocannabinoid system for the treatment of pain
• The Endocannabinoid System, Cannabinoids, and Pain
• The endogenous cannabinoid system and its role in nociceptive behavior
• The Pharmacologic and Clinical Effects of Medical Cannabis
• Use of prescription pain medications among medical cannabis patients: comparisons of pain levels, functioning, and patterns of alcohol and other drug use
• δ-Ctenitoxin-Pn1a, a Peptide from Phoneutria nigriventer Spider Venom, Shows Antinociceptive Effect Involving Opioid and Cannabinoid Systems, in Rats

 

Pancreatitis

 

• Anti-Inflammatory Role of Cannabidiol and O-1602 in Cerulein-Induced Acute Pancreatitis in Mice
• Cannabinoids Ameliorate Pain and Reduce Disease Pathology in Cerulein-Induced Acute Pancreatitis
• Cannabinoids Reduce Markers of Inflammation and Fibrosis in Pancreatic Stellate Cells

 

Parkinson’s

 

• Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
• *Effects of cannabinoids Δ(9)-tetrahydrocannabinol, Δ(9)-tetrahydrocannabinolic acid and cannabidiol in MPP+ affected murine mesencephalic cultures
• Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
• Self-Reported Efficacy of Cannabis and Other Complementary Medicine Modalities by Parkinson’s Disease Patients in Colorado
• Survey on Cannabis Use in Parkinson’s Disease: Subjective Improvement of Motor Symptoms
• The CB1 cannabinoid receptor agonist reduces L-DOPA-induced motor fluctuation and ERK1-2 phosphorylation in 6-OHDA-lesioned rats
• The influence of cannabinoids on generic traits of neurodegeneration

 

Patents

 

• Formulation And Method For Increasing Oral Bioavailability Of Drugs
• United States patent application publication for phytocannabinoids in the treatment of cancer
• United States patent on cannabinoids as antioxidants and neuroprotectants

 

Pediatric Acute-onset Neuropsychiatric Syndrome (PANS)

 

• Cannabinoids as novel anti-inflammatory drugs
• Cannabinoid-induced apoptosis in immune cells as a pathway to immunosuppression
• CB2 cannabinoid receptor agonist, JWH-015 triggers apoptosis in immune cells: Potential role for CB2 selective ligands as immunosuppressive agents

 

Pets

 

• Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

 

Pharmacokinetics

 

• Formulation And Method For Increasing Oral Bioavailability Of Drugs
• Human Cannabinoid Pharmacokinetics

 

Polycystic Ovary Syndrome (PCOS)

 

• Activation of cannabinoid CB1 receptors induces glucose intolerance in rats
• Cannabinoid Receptor 1 Gene Polymorphisms and Nonalcoholic Fatty Liver Disease in Women with Polycystic Ovary Syndrome and in Healthy Controls
• *Decreased expression of fatty acid amide hydrolase in women with polycystic ovary syndrome
• *Effects of cannabinoid antagonist-induced weight loss in polycystic ovarian syndrome (PCOS) patients
• Endocannabinoid receptor blockade reduces alanine aminotransferase in polycystic ovary syndrome independent of weight loss
• *Endocannabinoid system activation may be associated with insulin resistance in women with polycystic ovary syndrome
• Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes
• The endocannabinoid pathway and the female reproductive organs

 

Post Traumatic Stress Disorder (PTSD)

 

• Cannabinoids Prevent the Effects of a Footshock Followed by Situational Reminders on Emotional Processing
• Changes of endocannabinoid plasma levels following type I trauma: A prospective pilot study
• Elevated Brain Cannabinoid CB1 Receptor Availability in Posttraumatic Stress Disorder- A Positron Emission Tomography Study
• On Disruption of Fear Memory by Reconsolidation Blockade: Evidence from Cannabidiol Treatment
• PTSD Symptom Reports of Patients Evaluated for the New Mexico Medical Cannabis Program

 

Potential of whole plant vs. single compound model

 

• A tale of two cannabinoids: The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol
• Activity of cannabis in relation to its delta’-trans-tetrahydro-cannabinol content
• An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity
• Cannabidiol Enhances the Inhibitory Effects of Δ9-Tetrahydrocannabinol on Human Glioblastoma Cell Proliferation and Survival
• Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts
• Overcoming the Bell‐Shaped Dose‐Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol
• Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects

 

Pregnancy

 

• Cannabidiol changes P-gp and BCRP expression in trophoblast cell lines
• Fetal Alcohol Spectrum Disorder: Potential Role of Endocannabinoids Signaling
• Lasting impacts of prenatal cannabis exposure and the role of endogenous cannabinoids in the developing brain
• Multiple Roles for the Endocannabinoid System During the Earliest Stages of Life: Pre- and Postnatal Development
• The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease

 

Prostate Cancer

 

• Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK12 Leading to G1 Cell Cycle Arrest
• Cannabinoid receptor as a novel target for the treatment of prostate cancer
• Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R( þ )-Methanandamide and JWH-015: Involvement of CB2
• Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms
• Proapoptotic effect of endocannabinoids in prostate cancer cells
• The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications

 

Psoriasis

 

• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1-CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis

 

Psychiatry

 

• CBD Decreases Opioid and other addictions, such as Heroin – mouse studies. Cannabidiol decreases the “drug-seeking behavior”. The opposite of a “gateway drug”.

 

Pulmonary Function

 

• Association Between Marijuana Exposure and Pulmonary Function Over 20 Years
• Bronchodilator Effect Of Δ1-Tetrahydrocannabinol
• Cannabinoid effects on ventilation and breathlessness: a pilot study of efficacy and safety
• Does smoking marijuana increase the risk of chronic obstructive pulmonary disease
• Effects of Marijuana Smoking on the Lung
• Inhibition of guinea-pig and human sensory nerve activity and the cough reflex in guinea-pigs by cannabinoid (CB2) receptor activation
• Marijuana and chronic obstructive lung disease: a population-based study
• Monoacylglycerol Lipase (MAGL) Inhibition Attenuates Acute Lung Injury in Mice
• The effects of marijuana exposure on expiratory airflow. A study of adults who participated in the U.S. National Health and Nutrition Examination Study

 

Restless Leg Syndrome

 

• Cannabis for restless legs syndrome: a report of six patients
• *Cannabis, pain, and sleep: lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine

 

Rheumatoid Arthritis

 

• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
• Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
• Characterisation of the cannabinoid receptor system in synovial tissue and fluid in patients with osteoarthritis and rheumatoid arthritis
• A novel synthetic, nonpsychoactive cannabinoid acid (HU-320) with antiinflammatory properties in murine collagen-induced arthritis
• Cannabinoids: novel therapies for arthritis?
• Cannabinoids as novel anti-inflammatory drugs

 

Schizophrenia

 

• A clinical comparison of schizophrenia with and without pre-onset cannabis use disorder: a retrospective cohort study using categorical and dimensional approaches
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice
• Effects of cannabidiol on schizophrenia-like symptoms in people who use cannabis
• Effects of cannabinoid drugs on the deficit of prepulse inhibition of startle in an animal model of schizophrenia: the SHR strain

 

Sickle-cell Disease

 

• Cannabis use in sickle cell disease: a questionnaire study
• Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids

 

Sjögren’s Syndrome

 

• Cannabinoids as novel anti-inflammatory drugs
• The analgesic potential of cannabinoids

 

Skeletal System

 

• Activation of Cannabinoid Receptor 2 Enhances Osteogenic Differentiation of Bone Marrow Derived Mesenchymal Stem Cells
• Cannabinoid receptors and the regulation of bone mass
• Cannabinoids and bone: endocannabinoids modulate human osteoclast function in vitro
• Effects of deleting cannabinoid receptor-2 on mechanical and material properties of cortical and trabecular bone
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Protective Effects of Cannabidiol on Lesion-Induced Intervertebral Disc Degeneration
• Role of cannabinoids in the regulation of bone remodeling
• The Role Of Type 2 Cannabinoid Receptor In Bone Metabolism

 

Skin

 

• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities

 

Sleep Disorders

 

• A Longitudinal Study of Prenatal Marijuana Use
• A Pilot Study into the Effects of the CB1 Cannabinoid Receptor Agonist WIN55,212-2 or the Antagonist-Inverse Agonist AM251 on Sleep in Rats
• Administration of URB597, Oleoylethanolamide or Palmitoylethanolamide Increases Waking and Dopamine in Rats
• Around‐the‐Clock Oral THC Effects on Sleep in Male Chronic Daily Cannabis Smokers
• Effect of cannabis and certain of its constituents on pentobarbitone sleeping time and phenazone metabolism
• Effect of Δ-9-Tetrahydrocannabinol and Cannabidiol on Nocturnal Sleep and Early-Morning Behavior in Young Adults
• Endocannabinoid Signaling Regulates Sleep Stability
• Intrahippocampal administration of anandamide increases REM sleep
• Modulation of Sleep-Wake Cycles in Mice and Rats with Cannabinoids
• Proof of concept trial of dronabinol in obstructive sleep apnea

 

Spasticity

 

• A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex®), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis
• Cannabinoids in the management of spasticity associated with multiple sclerosis
• Clinical experiences with cannabinoids in spasticity management in multiple sclerosis
• Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study
• Sativex in the Management of Multiple Sclerosis-Related Spasticity: Role of the Corticospinal Modulation
• Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
• Symptomatic therapy in multiple sclerosis: the role of cannabinoids in treating spasticity
• Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review

 

Spinal Cord Disease

 

• A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms
• A survey of cannabis (marijuana) use and self-reported benefit in men with chronic prostatitis/chronic pelvic pain syndrome

 

Spinal Cord Injuries

 

• Early Endogenous Activation of CB1 and CB2 Receptors after Spinal Cord Injury Is a Protective Response Involved in Spontaneous Recovery
• Treatments for Chronic Pain in Persons With Spinal Cord Injury: A Survey Study

 

Sports Related

 

• Activation of Cannabinoid CB2 Receptor–Mediated AMPK-CREB Pathway Reduces Cerebral Ischemic Injury
• Activation of cortical type 2 cannabinoid receptors ameliorates ischemic brain injury
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• Cannabinoid receptors and the regulation of bone mass
• Cannabis Responsive Head Injury Induced Mutiple Disabilities: A Case Report
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia
• Endocannabinoids and traumatic brain injury
• Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
• HU­211, a Novel Noncompetitive N­Methyl­D­Aspartate Antagonist, Improves Neurological Deficit and Reduces
• Infarct Volume After Reversible Focal Cerebral Ischemia in the Rat
• Injury, Pain, and Prescription Opioid Use Among Former National Football League (NFL) Players
• Mechanisms of cannabidiol neuroprotection in hypoxic-ischemic newborn pigs: Role of 5HT1A and CB2 receptors
• Peripheral cannabinoid receptor, CB2, regulates bone mass
• Role of cannabinoids in the regulation of bone remodeling
• The Cannabinoid Agonist Win55212 Reduces Brain Damage in an In Vivo Model of Hypoxic-Ischemic Encephalopathy in Newborn Rats
• The endocannabinoid 2-AG protects the blood–brain barrier after closed head injury and inhibits mRNA expression of proinflammatory cytokines
• The Role Of Type 2 Cannabinoid Receptor In Bone Metabolism
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Tissue Engineering of Cartilage; Can Cannabinoids Help?
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

 

Staph (Infections)

 

• Is Cannabis the Solution to Antibiotic-Resistant Staph and Superbug Crisis?

 

Stroke

 

• Cannabinoids in experimental stroke: a systematic review and meta-analysis
• Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
• Update on the Role of Cannabinoid Receptors after Ischemic Stroke

 

Super Canal Dehiscence

 

• Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system

 

Thyroid

 

• Clinical Significance of Cannabinoid Receptors CB1 and CB2 Expression in Human Malignant and Benign Thyroid Lesions
• *Expression of the CB1 and CB2 receptor messenger RNAs during embryonic development in the rat
• Evidence for functional CB1 cannabinoid receptor expressed in the rat thyroid
• *Neuroprotective activity of cannabinoid receptor-2 against oxidative stress and apoptosis in rat pups having experimentally-induced congenital hypothyroidism
• The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance
• Type 1 Cannabinoid Receptor-Containing Axons Innervate Hypophysiotropic Thyrotropin-Releasing Hormone-Synthesizing Neurons

 

Tourette’s Syndrome

 

• *Cannabinoids for Tourette’s Syndrome (Review)
• Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome
• Cannabinoids reduce symptoms of Tourette’s syndrome
• *Delta 9-Tetrahydrocannabinol (THC) is Effective in the Treatment of Tics in Tourette Syndrome: a 6-Week Randomized Trial
• Influence of Treatment of Tourette Syndrome with Δ9-Tetrahydrocannabinol (Δ9-THC) on Neuropsychological Performance
• *Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome
• Significant Tic Reduction in An Otherwise Treatment-Resistant Patient with Gilles de la Tourette Syndrome Following Treatment with Nabiximols
• Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients
• Treatment of Tourette syndrome with cannabinoids (Review)
• *Treatment of Tourette-Syndrome with Δ9-Tetrahydrocannabinol (THC): a randomized crossover trial

 

Traumatic Brain Injury (TBI)

 

• Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
• An endogenous cannabinoid (2-AG) is neuroprotective after brain injury
• Cannabinoid agonist rescues learning and memory after a traumatic brain injury
• CB1 and CB2 Cannabinoid Receptor Antagonists Prevent Minocycline-Induced Neuroprotection Following Traumatic Brain Injury in Mice
• Early increase of cannabinoid receptor density after experimental traumatic brain injury in the newborn piglet
• Endocannabinoids and traumatic brain injury
• Estradiol Decreases Cortical Reactive Astrogliosis after Brain Injury by a Mechanism Involving Cannabinoid Receptors
• Preclinical evaluation of SMM-189, a cannabinoid receptor 2-specific inverse agonist

 

Tumors

 

• Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines
• The antitumor activity of plant-derived non-psychoactive cannabinoids

 

West Syndrome

 

• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy